| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
5DFR 1RA2 3DRC 1DRA 1RX1 4DFR 1DHI 1RF7 1RB3 3QL3 2ANO 2INQ 1RD7 1TDR 1DRE 1RX4 1RA3 1RX2 1DYI 1DRB 1RB2 1RX6 1RX8 7DFR 1DYH 1RA9 1RG7 1JOL 1RX9 2D0K 1DDS 3K74 3KFY 1RA1 1RX7 1DYJ 1JOM 1RA8 3DAU 3OCH 1RE7 6DFR 1DRH 1RX3 1DDR 1RH3 1RC4 1RX5 2DRC 1DHJ 2ANQ |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |