dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0042493	response to drug	BP
GO:0046677	response to antibiotic	BP
GO:0006545	glycine biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0031427	response to methotrexate	BP
GO:0004146	dihydrofolate reductase activity	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RE7 1RX5 1RA8 3KFY 1RX8 1RB2 1RX1 2ANQ 1RF7 1RA2 1DRB 1DRE 2D0K 1RD7 6DFR 1DDS 1RG7 1RC4 1RA9 1DHJ 1DHI 1RX2 3QL3 3DRC 5DFR 7DFR 2ANO 1DRA 1JOL 1JOM 2DRC 2INQ 1RX9 1TDR 1DDR 1RX7 1RB3 1RA1 1DYI 1RH3 3K74 1DYJ 1RX3 3OCH 1DRH 1RX6 1DYH 3DAU 1RX4 1RA3 4DFR
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference