dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0046677	response to antibiotic	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0042493	response to drug	BP
GO:0031427	response to methotrexate	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0004146	dihydrofolate reductase activity	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	3DRC 1RA8 7DFR 1DDR 1DDS 1DYI 4DFR 1JOL 1RA3 1RX3 1RG7 1RD7 3K74 3QL3 1RB2 3OCH 1TDR 1RA9 1DRA 1RA1 1RX9 2ANQ 1RX8 1DRE 1RX1 1RH3 1RA2 2DRC 1DHI 1RX5 2D0K 1DYH 2ANO 1RC4 1RX2 1DRH 1RX7 1RB3 5DFR 3DAU 1RE7 1JOM 6DFR 1RX6 1RX4 1DHJ 1DYJ 1DRB 2INQ 3KFY 1RF7
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference