| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0031427 | response to methotrexate | BP |
| GO:0042493 | response to drug | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1JOM 1RX1 3KFY 1DHI 1RA8 1RA2 1RX2 2ANQ 1DYI 2ANO 3QL3 1RH3 3DRC 1DRE 1RX4 3OCH 1RX3 3DAU 1RX7 1DDS 2INQ 1RA9 1RX9 1DRH 1RX5 1RE7 1DRB 1RB3 1RA3 2D0K 1DHJ 7DFR 1DRA 1DDR 6DFR 1RB2 1RX8 1TDR 5DFR 3K74 1DYJ 1RA1 1RF7 1RX6 1JOL 2DRC 4DFR 1RG7 1RC4 1DYH 1RD7 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |