| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0046677 | response to antibiotic | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RB2 1RX3 3KFY 6DFR 2ANQ 1RG7 1RF7 2INQ 3OCH 1DYJ 1RA2 1DHJ 1RX9 3K74 2D0K 1RA8 1DYI 3QL3 1RB3 2DRC 1RA1 1DDR 1JOL 3DRC 1DHI 1RX6 1RX1 1DRB 1RX4 1JOM 1RX7 1RX2 1RX5 4DFR 1DYH 1RD7 1RH3 1RA3 7DFR 1DDS 2ANO 1RA9 1DRA 1RC4 1RE7 1RX8 5DFR 1DRE 1DRH 3DAU 1TDR |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |