dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0042493	response to drug	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0046677	response to antibiotic	BP
GO:0006730	one-carbon metabolic process	BP
GO:0031427	response to methotrexate	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	6DFR 1JOL 1RX9 2INQ 2D0K 1RX1 1JOM 2ANQ 7DFR 3OCH 1DHJ 1DYJ 3K74 1DRE 1RX2 3KFY 1DRA 1DRH 1RA1 1RX4 3DAU 4DFR 1DRB 1RA9 1RX7 1DDS 1RH3 5DFR 1RF7 2ANO 1RB3 1RX8 1DHI 1RX5 1RA8 1RE7 1DYI 1DYH 1DDR 1RA2 1RB2 2DRC 3DRC 1RX6 1RG7 1RA3 1TDR 1RD7 1RX3 1RC4 3QL3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference