dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0050661	NADP binding	MF
GO:0031427	response to methotrexate	BP
GO:0046677	response to antibiotic	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0006730	one-carbon metabolic process	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX1 1RA3 3QL3 1RX5 2DRC 1RA2 1RF7 1RX3 6DFR 1RD7 3DAU 3DRC 1RG7 3OCH 1RH3 3KFY 1TDR 1RC4 1DDR 2D0K 1RX6 1RA8 1DYI 2ANQ 1DYH 1DRE 1RX7 2ANO 1JOM 3K74 1RX8 7DFR 1DYJ 1DRB 1RB2 1DHI 1RX4 2INQ 1RX9 1DRH 1DDS 1RX2 1JOL 4DFR 1RE7 5DFR 1RA1 1RB3 1RA9 1DRA 1DHJ
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

Options for BLAST

Database:

Set subsequence:(optional):

Optional parameters:

Database Cross Reference