dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0004146	dihydrofolate reductase activity	MF
GO:0031427	response to methotrexate	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0042493	response to drug	BP
GO:0046677	response to antibiotic	BP
GO:0006730	one-carbon metabolic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0050661	NADP binding	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX3 1RG7 1RH3 1RB2 1RX4 1RA8 1RX2 1RA2 3QL3 1DYJ 1DRE 1TDR 3DAU 1JOM 1RA1 3OCH 2ANQ 2ANO 1RC4 1DYI 1DRA 1RB3 4DFR 1DRB 1DHI 3DRC 1DDR 1RX9 1DRH 1RA9 3KFY 1RF7 3K74 1JOL 1RX6 1RE7 1RD7 1RX5 6DFR 7DFR 1DYH 1DHJ 2D0K 1RX7 5DFR 2DRC 1DDS 1RX1 1RX8 2INQ 1RA3
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference