dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0042493	response to drug	BP
GO:0031427	response to methotrexate	BP
GO:0004146	dihydrofolate reductase activity	MF
GO:0050661	NADP binding	MF
GO:0009165	nucleotide biosynthetic process	BP
GO:0006730	one-carbon metabolic process	BP
GO:0006545	glycine biosynthetic process	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0046677	response to antibiotic	BP

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1RX3 1RX2 1RX5 3KFY 1RD7 3OCH 1TDR 1RG7 3K74 1DRB 5DFR 1DDS 1JOM 1DYI 1DRE 1RA8 2INQ 3QL3 1RA1 1RC4 1DDR 4DFR 1RX4 1RX7 3DRC 1RA2 1RE7 1RX8 6DFR 1DRA 1RA9 1RA3 1RF7 3DAU 1DHI 1RX9 1RX6 1JOL 1DRH 1DYJ 1RB2 7DFR 2ANO 2D0K 1RX1 2ANQ 1RB3 1DHJ 1DYH 1RH3 2DRC
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference