| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0042493 | response to drug | BP |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0031427 | response to methotrexate | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0006545 | glycine biosynthetic process | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RX7 1RH3 2ANO 1DDR 1JOM 1RX4 3DAU 1RA8 1RA2 1JOL 1RA1 6DFR 1RX6 3KFY 1DRB 1DRH 2D0K 2INQ 1RE7 1RG7 2ANQ 1RX1 1DHI 1DDS 1RX5 4DFR 1RA9 3DRC 1RC4 1RX9 1RA3 1RX2 1TDR 1DRA 3OCH 1RB2 5DFR 1RX8 3QL3 1RD7 1DYJ 1DHJ 2DRC 1DYI 1RF7 7DFR 1DRE 1RX3 3K74 1DYH 1RB3 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |