dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

Text mining Term	dihydrofolate reductase
UniProt ID	DYR_ECOLI
Name	Dihydrofolate reductase
Gene Names	folA Synonyms:tmrA
Taxonomy	Escherichia coli K-12

General annotation

Function	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Subcellular location

Gene Ontology

GO:0031427	response to methotrexate	BP
GO:0042493	response to drug	BP
GO:0009257	10-formyltetrahydrofolate biosynthetic process	BP
GO:0009165	nucleotide biosynthetic process	BP
GO:0050661	NADP binding	MF
GO:0006545	glycine biosynthetic process	BP
GO:0046677	response to antibiotic	BP
GO:0006730	one-carbon metabolic process	BP
GO:0004146	dihydrofolate reductase activity	MF

Sequence

>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655]
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD
RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF
HDADAQNSHSYCFEILERR

Database Cross Reference

Ensembl Gene
UniGene
PDB	1DRA 1DDR 1RD7 1DRH 1RX9 3QL3 1DYJ 1RX5 1RA2 1DHJ 1JOL 1RA1 3DAU 2INQ 1DYH 1RX8 1RX7 3DRC 1TDR 1DDS 2ANQ 1DRE 1RX6 1RA3 1DRB 2DRC 1RX1 1RX2 5DFR 1RX3 1RB2 1DYI 3K74 1JOM 1RX4 2D0K 7DFR 1RC4 4DFR 1RA9 1DHI 1RF7 2ANO 3KFY 6DFR 1RB3 1RH3 1RG7 1RA8 3OCH 1RE7
RefSeq	NP_414590.1
Pfam	PF00186

PTID

dihydrofolate reductase

General Information (Source: NCBI Gene,UniProt)

General annotation

Gene Ontology

Sequence

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Database Cross Reference