| Text mining Term | dihydrofolate reductase |
|---|---|
| UniProt ID | DYR_ECOLI |
| Name |
Dihydrofolate reductase |
| Gene Names |
folA
Synonyms:tmrA |
| Taxonomy | Escherichia coli K-12 |
| Function |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. |
|---|---|
| Subcellular location |
| GO:0031427 | response to methotrexate | BP |
| GO:0006545 | glycine biosynthetic process | BP |
| GO:0050661 | NADP binding | MF |
| GO:0004146 | dihydrofolate reductase activity | MF |
| GO:0006730 | one-carbon metabolic process | BP |
| GO:0046677 | response to antibiotic | BP |
| GO:0009257 | 10-formyltetrahydrofolate biosynthetic process | BP |
| GO:0009165 | nucleotide biosynthetic process | BP |
| GO:0042493 | response to drug | BP |
>gi|16128042|ref|NP_414590.1| dihydrofolate reductase [Escherichia coli str. K-12 substr. MG1655] MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILSSQPGTDD RVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFPDYEPDDWESVFSEF HDADAQNSHSYCFEILERR |
| Ensembl Gene | |
|---|---|
| UniGene | |
| PDB |
1RA1 1RB3 4DFR 1DHI 1RX1 1RB2 5DFR 2DRC 3K74 2INQ 3QL3 1TDR 3DRC 3OCH 6DFR 1RX2 1RD7 1RA3 7DFR 1DYH 2D0K 1DRH 2ANQ 2ANO 1DHJ 1DDS 1RX7 1DRE 1RH3 3KFY 1DRA 1RF7 1RE7 1DRB 1RA8 1RX6 1RX3 1RA9 1RX8 1RG7 1RC4 3DAU 1RA2 1DYJ 1RX4 1RX5 1JOM 1DDR 1JOL 1DYI 1RX9 |
| RefSeq |
NP_414590.1 |
| Pfam |
PF00186 |