| 588267 |
Roobol A, Gull K, Pogson CI: Griseofulvin-induced aggregation of microtubule protein. Biochem J. 1977 Oct 1;167(1):39-43.
Griseofulvin (7-chloro-2',4,6-trimethoxy-6'-methylspiro [benzofuran-2 (3H),1'-[2] cyclohex ene]-3,4'-dione) induces aggregation of microtubule protein at 0 degrees C. This aggregate contains approx. 90% of the microtubule-associated proteins originally present in the microtubule protein. The supernatant obtained after removal of the griseofulvin-induced aggregate does not form microtubules on warming at 37 degrees C. Addition of the griseofulvin-aggregated protein to this supernatant and warming to 37 degrees C gives rise to a limited amount of microtubule assembly. The possible involvement of griseofulvin-induced aggregation of microtubule protein at 0 degrees C in the inhibition by griseofulvin of microtubule assembly in vitro is discussed. |
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