| Name | vitamin K epoxide reductase |
|---|---|
| Synonyms | Vitamin K epoxide reductase; IMAGE3455200; MST134; MST576; MSTP134; MSTP576; Phylloquinone epoxide reductase; UNQ308… |
| Name | difenacoum |
|---|---|
| CAS |
| PubMed | Abstract | RScore(About this table) | |
|---|---|---|---|
| 6807339 | Hildebrandt EF, Suttie JW: Mechanism of action: sensitivity of metabolizing enzymes of normal and -resistant rat liver. Biochemistry. 1982 May 11;21(10):2406-11. The anticoagulant difenacoum is an effective rodenticide in the -resistant strain of rats, and the only enzyme studied from -resistant rat liver that demonstrated a significant differential inhibition by the two used was the vitamin K epoxide reductase. |
88(1,1,2,3) | Details |
| 19752778 | Grandemange A, Kohn MH, Lasseur R, Longin-Sauvageon C, Berny P, Benoit E: Consequences of the Y139F Vkorc1 mutation on resistance to AVKs: in-vivo investigation in a 7th generation of congenic Y139F strain of rats. Pharmacogenet Genomics. 2009 Oct;19(10):742-50. However, the physiological response to the super-warfarins, difenacoum and difethialone, may be strongly dependent on other genes located outside the congenic interval (28.3 cM) bracketing the Vkorc1 in our F7 generation congenic strain. |
11(0,0,1,6) | Details |
| 2424118 | Wallin R, Patrick SD, Ballard JO: antagonism of intoxication in the rat. Thromb Haemost. 1986 Apr 30;55(2):235-9. An in vitro system which expresses all enzyme activities related to -dependent carboxylation of blood clotting factors was prepared from livers of rats overdosed with difenacoum and dicumarol respectively. Vitamin K epoxide reductase was also inactive which strongly suggests that this enzyme catalyzes the activity of pathway I in vivo. |
1(0,0,0,1) | Details |
| 3978316 | Breckenridge AM, Cholerton S, Hart JA, Park BK, Scott AK: A study of the relationship between the pharmacokinetics and the pharmacodynamics of the anticoagulants difenacoum and brodifacoum in the rabbit. Br J Pharmacol. 1985 Jan;84(1):81-91. |
0(0,0,0,0) | Details |