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trichlorfon

Identification (Source:EPA,EU)

ID	247
Name	trichlorfon
CAS	52-68-6
IUPAC
Inchi	InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3
CIPAC	68
EPA Code	057901
Formula	C4H8Cl3O4P
SMILES	COP(=O)(C(C(Cl)(Cl)Cl)O)OC
Status	Not Approved

Classification

Mode of Action	Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
Pesticide Type	Insecticide, Veterinary treatment
Chemical Group	Organophosphate
Classification	phosphonate insecticides phosphonate acaricides

Properties (Source:PubChem)

Molecular Weight	257.4
Physical State	Colourless to yellow or pink waxy solid
AlogP	0.753
H-Bond Donor	1
H-Bond Acceptor	4
Surface Area	224.93
Polar Surface Area	65.56

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	3.2 mg l-1
Algae	Acute	72 hour	EC50, growth	10 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.00096 mg l-1
Birds	Acute		LD50	> 36.8 mg kg-1
Fish	Acute	96 hour	LC50	0.7 mg l-1
Honeybees	Acute	48 hour	LD50	> 0.4 μg bee-1
Mammals	Acute oral		LD50	212 mg kg-1
Mammals	Short term dietary		NOEL	> 4.5 mg kg-1
Mammals	Short term dietary		NOEL	> 500 ppm diet
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
cholinesterases	978(6,12,17,293)	Details
Acetylcholinesterase	636(3,8,11,231)	Details
P450scc	193(2,3,3,3)	Details
steroidogenic acute regulatory protein	162(2,2,2,2)	Details
neurotoxic esterase	96(1,1,1,16)	Details
superoxide dismutase	90(1,1,2,5)	Details
CS2	88(1,1,2,3)	Details
caspase 3	93(0,3,3,3)	Details
caspase 12	62(0,2,2,2)	Details
cytochrome c	62(0,2,2,2)	Details
brains	38(0,1,1,8)	Details
lactate dehydrogenase (protein family or complex)	35(0,1,1,5)	Details
calcium channel (protein family or complex)	32(0,1,1,2)	Details
ADAS	23(0,0,0,23)	Details

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