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abamectin

Identification (Source:EPA,EU)

ID	163
Name	abamectin
CAS	71751-41-2
IUPAC
Inchi	InChI=1S/C48H72O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,17-19,25-26,28,30-31,33-45,49-50,52H,11,16,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
CIPAC	495
EPA Code	122804
Formula	C48H72O14 (avermectin B1a) + C47H70O14 (avermectin B1b)
SMILES	O=C6OC2CC(OC1(OC[C@H](CC1)C)C2)C/C=C(/C)[C@@H](OC4O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C4)C(/C=C\C=C5/[C@]7(O)C(OC5)[C@H](O)C(=C/C67)\C)C
Status	Approved

Classification

Mode of Action	Contact and stomach action with limited systemic activity, blocks electrical activity in nerves and muscles of pest
Pesticide Type	Insecticide, Acaricide, Nematicide, Metabolite, Veterinary treatment
Chemical Group	Micro-organism derived
Classification	avermectin insecticides avermectin nematicides avermectin acaricides

Properties (Source:PubChem)

Molecular Weight	866.6
Physical State	Fine white powder
AlogP	8.928
H-Bond Donor	6
H-Bond Acceptor	28
Surface Area	1679.05
Polar Surface Area	340.12

Structure

Ecotoxicology (Source:PPDB,IPM)

Species	Method	Study Time	Dose Type	Value
Algae	Chronic	96 hour	NOEC, growth	21.3 mg l-1
Algae	Acute	72 hour	EC50, growth	> 1.59 mg l-1
Aquatic invertebrates	Acute	48 hour	EC50	0.00012 mg l-1
Aquatic invertebrates	Chronic	21 day	NOEC	0.01 mg l-1
Aquatic plants	Acute	7 day	EC50, biomass	3.9 mg l-1
Birds	Short term dietary		LC50/LD50	48.6 mg/kg bw/day
Birds	Short term dietary		LC50/LD50	48.6 mg/kg bw/day
Birds	Acute		LD50	77 mg kg-1
Birds	Acute		LD50	77 mg kg-1
Earthworms	Acute	14 day	LD50	33 mg kg-1
Earthworms	Chronic	14 day	NOEC, reproduction	0.72 mg kg-1
Fish	Acute	96 hour	LC50	0.0036 mg l-1
Fish	Chronic	21 day	NOEC	0.52 mg l-1
Honeybees	Acute	48 hour	LD50	0.0022 μg bee-1
Mammals	Acute oral		LD50	8.7 mg kg-1
Mammals	Acute oral		LD50	8.7 mg kg-1
Mammals	Short term dietary		NOEL	4.5 mg kg-1
Mammals	Short term dietary		NOEL	4.5 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.000081 mg kg-1
Sediment dwelling organisms	Chronic	28 day	NOEC, sediment	0.0033 mg kg-1
	Bio-concentration factor		BCF	69
	Bio-concentration factor		CT50	Not available days
	Bio-concentration factor		BCF	69
	Bio-concentration factor		CT50	Not available days

Related targets

Target Name	RScore (About this table)
P glycoprotein	134(1,2,3,19)	Details
catalase	31(0,1,1,1)	Details
superoxide dismutase	31(0,1,1,1)	Details
glutathione S transferase	31(0,1,1,1)	Details
acid phosphatase	31(0,1,1,1)	Details
alkaline phosphatase	31(0,1,1,1)	Details
follicle stimulating hormone (protein family or complex)	31(0,1,1,1)	Details
Acetylcholinesterase	31(0,1,1,1)	Details
CF 1 (protein family or complex)	14(0,0,2,4)	Details
muscles	13(0,0,2,3)	Details
aspartate aminotransferase	12(0,0,2,2)	Details
C18	11(0,0,0,11)	Details
chloride channel (protein family or complex)	10(0,0,0,10)	Details

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