thiamethoxam

Identification (Source:EPA,EU)

ID 1459
Name thiamethoxam
CAS 153719-23-4
IUPAC
Inchi InChI=1S/C8H10ClN5O3S/c1-12-4-17-5-13(8(12)11-14(15)16)3-6-2-10-7(9)18-6/h2H,3-5H2,1H3
CIPAC 637
EPA Code 060109
Formula C8H10ClN5O3S
SMILES Clc1ncc(s1)CN2\C(=N\[N+]([O-])=O)N(C)COC2
Status Approved

Classification

Mode of Action Broad spectrum, systemic with contact and stomach action. Acetylcholine receptor (nAChR) agonist.
Pesticide Type Insecticide
Chemical Group Neonicotinoid
Classification thiazole insecticides
nitroguanidine nicotinoid insecticides

Properties (Source:PubChem)

Molecular Weight 291.71
Physical State Crystalline powder
AlogP 2.689
H-Bond Donor 0
H-Bond Acceptor 7
Surface Area 270.97
Polar Surface Area 115.01

Structure



ChemMapper Search Option (Docunmentation of ChemMapper)

3D similarity method

2D similarity method

Compound Database



Bioactivity Database

KEGG (5,928)

PDB (7,072)


Similarity Threshold

Ecotoxicology (Source:PPDB,IPM)

Species Method Study Time Dose Type Value
Algae Acute 72 hour EC50, growth > 100 mg l-1
Aquatic invertebrates Acute 48 hour EC50 > 100 mg l-1
Aquatic plants Acute 7 day EC50, biomass > 90 mg l-1
Birds Acute LD50 576 mg kg-1
Birds Short term dietary LC50/LD50 > 2503 mg/kg feed
Earthworms Chronic 14 day NOEC, reproduction 5.34 mg kg-1
Earthworms Acute 14 day LD50 > 1000 mg kg-1
Fish Acute 96 hour LC50 > 125 mg l-1
Fish Chronic 21 day NOEC 20 mg l-1
Honeybees Acute 48 hour LD50 0.005 μg bee-1
Mammals Acute oral LD50 > 1563 mg kg-1
Sediment dwelling organisms Chronic 28 day NOEC, sediment 0.01 mg kg-1
Sediment dwelling organisms Chronic 28 day NOEC, sediment 0.10 mg kg-1

Related targets

Target Name RScore (About this table)
acetylcholine receptors (protein family or complex) 271(2,5,6,16) Details
Acetylcholinesterase 33(0,1,1,3) Details
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