6HM6

Spleen tyrosine kinase

RCSB Kinase

Target Species: Human
Kinase Family: Syk
Kinase Group: TK
Mutation: No

Resolution: 2.1
Release Year: 2018

Kinase Alias: SYK
Downstream Molecules: BTK, BLNK, GAB2
Associated Diseases: Breast Cancer

Ligand ID: GDK

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu449, Met450, Ala451
Binding Data: ~
Ligand SMILES: n1c(c2ccc(cc2)C)c(ccc1)OCc1ccccn1
Reference: 10.1016/j.bmcl.2018.09.022