6BRJ

Epithelial discoidin domain-containing receptor 1 DDR1

RCSB Kinase

Target Species: Human
Kinase Family: DDR
Kinase Group: TK
Mutation: No

Resolution: 2.231
Release Year: 2018

Kinase Alias: PTK3, EDDR1, NTRK4, DDR, DDR1, trkE, CD167, CAK, RTK6, PTK3A, TRKE, MCK10, NEP
Downstream Molecules: ERK, JAK2
Associated Diseases: Osteosarcoma, Pancreatic Cancer

Ligand ID: VX6

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Met667, Tyr666, Asp665
Binding Data: ~
Ligand SMILES: N1(CCN(CC1)C1=NC(=[N]=C(C1)NC1=NN=C(C1)C)Sc1ccc(cc1)NC(=O)C1CC1)C
Reference: 10.1016/j.chembiol.2018.11.005