6AAK

Tyrosine-protein kinase jak3

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TKL
Mutation: No

Resolution: 2.67
Release Year: 2018

Kinase Alias: JAKL, LJAK, JAK3, L-JAK, JAK-3, JAK3_HUMAN
Downstream Molecules: STAT3, PI3K
Associated Diseases: Non-Small Cell Lung Cancer, T-Cell Acute Lymphoblastic Leikemia

Ligand ID: 9T6

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Leu905, Tyr904, Glu903
Binding Data: ~
Ligand SMILES: C1=C2[C@@H](C(=CN=C2N=C1)C(=O)N)N[C@@H]1[C@@H]2C[C@@H]3C[C@H]1C[C@@](C3)(C2)O
Reference: 10.1016/j.bmc.2018.08.005