5XDK

Epidermal growth factor receptor EGFR

RCSB Kinase

Target Species: Human
Kinase Family: EGFR
Kinase Group: TK
Mutation: No

Resolution: 2.346
Release Year: 2017

Kinase Alias: ERBB, ERBB1, EGFR, mENA, EGFRvIII
Downstream Molecules: JAK, Src, Shc
Associated Diseases: Cancer

Ligand ID: 8JC

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Pro794, Met793, Leu792
Binding Data: ~
Ligand SMILES: c1(c(cnc(n1)Nc1ccc(cc1OC)N1CCN(CC1)C(=O)C)C(F)(F)F)Nc1cccc(c1)NC(=O)CC
Reference: 10.18632/oncotarget.18588