5UT5

Tyrosine-protein kinase JAK2

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 1.9
Release Year: 2017

Kinase Alias: JAK2
Downstream Molecules: STAT3, PI3K
Associated Diseases: Polycythemia Vera, Myelofibrosis

Ligand ID: 2HB

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Lys630, Val629, Ser628
Binding Data: Kd=50uM
Ligand SMILES: c1(CN2CCS(C=C2)(O)O)ccc(cc1)c1cccc2[n+]1[nH]c(NC(=O)C1CC1)n2
Reference: 10.1021/acsmedchemlett.7b00154