5QIN

TGF-beta receptor type-2 TGFBR2

RCSB Kinase

Target Species: Human
Kinase Family: STKR
Kinase Group: TKL
Mutation: E431A,R433A,E485A,K488A,R493A,R495A

Resolution: 1.57
Release Year: 2018

Kinase Alias: TAAD2, TGFbR2, HNPCC6, MFS2, TbetaR-II, TGFBR2, TGFR-2, TGFbeta-RII, TbetaRII, RIIC, AAT3, TGF_beta_RII, FAA3
Downstream Molecules: DAXX, SMAD3
Associated Diseases: Colorectal Cancer, Hepatocellular Carcinoma

Ligand ID: J2V

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: His328, Ser327, Ala326
Binding Data: ~
Ligand SMILES: c1c(ccc(n1)OC)c1c2c(cccn2)[nH]c1c1cc(ncc1)NC(=O)C
Reference: 10.1021/acsmedchemlett.8b00357