5QIM

TGF-beta receptor type I TGFBR1

RCSB Kinase

Target Species: Human
Kinase Family: STKR
Kinase Group: TKL
Mutation: No

Resolution: 1.75
Release Year: 2018

Kinase Alias: TGFbR1, TGF_beta_RI, AAT5, TbetaR-I, TGFBR1, ACVRLK4, ALK-5, ALK5, TGFR-1, SKR4
Downstream Molecules: DAXX, SMAD3
Associated Diseases: Gastric Cancer, Loeys-Dietz Syndrome

Ligand ID: J2Y

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Asp281, Tyr282, His283
Binding Data: ~
Ligand SMILES: c1c(ccc(c2c3c(cccn3)[nH]c2c2cc(ncc2)NC(=O)C)n1)OC
Reference: 10.1021/acsmedchemlett.8b00357