5P9L

Tyrosine-protein kinase BTK

RCSB Kinase

Target Species: Human
Kinase Family: TEC
Kinase Group: TK
Mutation: No

Resolution: 1.25
Release Year: 2017

Kinase Alias: AGMX1, IMD1, PSCTK1, BPK, ATK, XLA, MGC126261, MGC126262, AT, BTK
Downstream Molecules: PLCy
Associated Diseases: Chronic Lymphocytic Leukaemia; Rheumatoid Arthritis

Ligand ID: 7G9

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Met477, Tyr476, Glu475
Binding Data: ~
Ligand SMILES: c1(cnc(nc1Nc1cc(NC(=O)C=C)ccc1)Nc1ccc(cc1)OCCOC)F
Reference: 10.1124/mol.116.107037