5OQ8

Serine/threonine-Transferase CHK1

RCSB Kinase

Target Species: Human
Kinase Family: CAMKL
Kinase Group: CAMK
Mutation: No

Resolution: 2
Release Year: 2017

Kinase Alias: CHEK1, CHK1, p56Chk1
Downstream Molecules: PLK1, BLM, Mad2
Associated Diseases: Gastric Cancer, Head And Neck Cancer, Pancreatic Cancer

Ligand ID: A0Q

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ala87, Leu86, Glu85
Binding Data: Ki=1.41uM
Ligand SMILES: c1c(c(ccc1N1CCN(CC1)C)OCc1ccccc1)C(=O)Nc1cccnc1
Reference: 10.1021/acs.jmedchem.7b01186