5OQ6

Serine/threonine-Transferase CHK1

RCSB Kinase

Target Species: Human
Kinase Family: CAMKL
Kinase Group: CAMK
Mutation: No

Resolution: 1.95
Release Year: 2017

Kinase Alias: CHEK1, CHK1, p56Chk1
Downstream Molecules: PLK1, BLM, Mad2
Associated Diseases: Gastric Cancer, Head And Neck Cancer, Pancreatic Cancer

Ligand ID: 4K4

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ala87, Leu86, Glu85
Binding Data: Ki=0.0277uM
Ligand SMILES: c12c(cnc(n1)Nc1c(cc(C(=O)N3CCC(N4CCN(C)CC4)CC3)cc1)OC)n(c(=O)c1c(n2C)cccc1)C
Reference: 10.1021/acs.jmedchem.7b01186