5OPV

Serine/threonine-Transferase CHK1

RCSB Kinase

Target Species: Human
Kinase Family: CAMKL
Kinase Group: CAMK
Mutation: No

Resolution: 1.9
Release Year: 2017

Kinase Alias: CHEK1, CHK1, p56Chk1
Downstream Molecules: PLK1, BLM, Mad2
Associated Diseases: Gastric Cancer, Head And Neck Cancer, Pancreatic Cancer

Ligand ID: A3H

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ala87, Leu86, Glu85
Binding Data: IC50=8nM
Ligand SMILES: [NH+]1=C2N=CC(=C2C(=C/C/1=N\c1nn(cc1)C)c1cccc(c1)C)C#N
Reference: 10.1021/acs.jmedchem.7b01186