5O3F

Bromodomain-containing protein 2

RCSB Kinase

Target Species: Human
Kinase Family: BRD
Kinase Group: Atypical
Mutation: L/V mutant

Resolution: 1.75
Release Year: 2017

Kinase Alias: KIAA9001, NAT, FSRG1, RING3, D6S113E, FLJ31942, DKFZp686N0336, RNF3, BRD2
Downstream Molecules: NF-κB, c-MYC
Associated Diseases: Cancer

Ligand ID: 9HT

RCSB Ligand

Ligand Type: Competitive Inhibitor
Binding Pocket: BRD domain
Key Interaction Residues: Asn156, Ile162, Tyr155
Binding Data: ~
Ligand SMILES: CCNC(=O)[C@H](CC)[C@@H]1N=C(c2c(n3c1nnc3C)ccc(OC)c2)c1ccc(Cl)cc1
Reference: 10.1039/c7sc02536j