5O12

Serine/threonine-protein kinase PIM1

RCSB Kinase

Target Species: Human
Kinase Family: PIM
Kinase Group: CAMK
Mutation: No

Resolution: 2.4
Release Year: 2017

Kinase Alias: PIM, PIM1
Downstream Molecules: MAP3K5, MYC
Associated Diseases: Acute Myeloid Leukemia, Breast Cancer

Ligand ID: 1RO

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Pro123, Arg122, Glu121
Binding Data: ~
Ligand SMILES: O=C1N=C(NCc2cccs2)S[C@@H]1Cc1ccc2ncccc2c1.n1c[nH]cc1
Reference: 10.1038/s41598-017-13557-z