5N7V

Dual specificity protein kinase TTK

RCSB Kinase

Target Species: Human
Kinase Family: TTK
Kinase Group: Other
Mutation: No

Resolution: 2.52
Release Year: 2017

Kinase Alias: TTK, MPS1L1, PYT, ESK, FLJ38280
Downstream Molecules: AKT
Associated Diseases: Hepatocellular Carcinoma, Breast Cancer

Ligand ID: 8PT

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Gly605, Cys604, Glu603
Binding Data: IC50=1.9nM
Ligand SMILES: [C@H]12[C@H]([C@H](NC3CCCCC3)N/C(=N\c3c(C)cc(cc3)N3CCOCC3)/[NH+]2)NCN1
Reference: 10.1016/j.jmb.2017.05.014