5L2S

Cyclin-dependent kinase 6 CDK6

RCSB Kinase

Target Species: Human
Kinase Family: CDK
Kinase Group: CMGC
Mutation: No

Resolution: 2.27
Release Year: 2016

Kinase Alias: MGC59692, PLSTIRE, CDK6
Downstream Molecules: Rb
Associated Diseases: Psoriasis, Bladder Cancer

Ligand ID: 6ZV

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Asp102, Val101, His100
Binding Data: Kd=83nM
Ligand SMILES: C(C)N1CCN(CC1)Cc1ccc(nc1)Nc1ncc(c(c2cc3c(c(c2)F)nc(C)n3C(C)C)n1)F
Reference: 10.1158/1535-7163.MCT-16-0300