5K0X

Tyrosine-protein kinase Mer MERTK

RCSB Kinase

Target Species: Human
Kinase Family: Axl
Kinase Group: TK
Mutation: No

Resolution: 2.231
Release Year: 2017

Kinase Alias: C-MER, MER, MGC133349, MERTK, mer, c-mer
Downstream Molecules: MAPK1, MAPK2
Associated Diseases: Retinitis Pigmentosa, Head And Neck Cancer

Ligand ID: K0X

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Met674, Ser673, Pro672
Binding Data: IC50=4.4nM
Ligand SMILES: C1CCCNC(=O)[C@@H](N)CCCC/[NH]=C\2/[C@H](C[NH2+][C@H](N2)NCC1)C(=O)NCc1ccc(F)cc1
Reference: 10.1002/cmdc.201600589