5J9L

Mitogen-activated protein kinase kinase kinase 7, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

RCSB Kinase

Target Species: Human
Kinase Family: Other
Kinase Group: Other
Mutation: No

Resolution: 2.7515
Release Year: 2017

Kinase Alias: MAP3K7IP1,TAB1
Downstream Molecules: TAK1, IKBKB, CHUK
Associated Diseases: Ovarian Cancer

Ligand ID: 6HF

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ala107, Tyr106, Glu105
Binding Data: IC50=34nM
Ligand SMILES: CN1CCN(CC1)c1ccc(cc1)Nc1nc2c(cc[nH]2)c(Oc2ccc(NC(=O)C=C)cc2)n1
Reference: 10.1016/j.bmc.2016.11.035