5F60

Bromodomain-containing protein 4

RCSB Kinase

Target Species: Human
Kinase Family: BRD
Kinase Group: Atypical
Mutation: No

Resolution: 1.35
Release Year: 2015

Kinase Alias: BRD4, MCAP, CAP, HUNKI
Downstream Molecules: NF-κB, c-MYC
Associated Diseases: Cancer

Ligand ID: 5VZ

RCSB Ligand

Ligand Type: Competitive Inhibitor
Binding Pocket: BRD domain
Key Interaction Residues: Asn156, Ile162, Tyr155
Binding Data: Kd=43nM
Ligand SMILES: c1c(Cl)c(NS(=O)(=O)C(C)(C)C)cc(c1)NC1=[N]=[C](=NC=C1C)Nc1ccc(N2CCN(C)CC2)cc1
Reference: 10.1158/1535-7163.MCT-16-0568-T