5DXH

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

RCSB Kinase

Target Species: Human
Kinase Family: PI3K/PI4K
Kinase Group: other
Mutation: No

Resolution: 3
Release Year: 2016

Kinase Alias: PIK3CA
Downstream Molecules: PIP3, Akt
Associated Diseases: Gastric Cancercolon Cancer

Ligand ID: 5H2

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Asn853, SER854, His855
Binding Data: Ki=0.2nM
Ligand SMILES: c1c(NC(=O)OC)cc2c(c1)c1c(CCO2)cc(s1)c1nncn1c1ccccc1Cl
Reference: 10.1021/acs.jmedchem.5b01483