5AAF

Aurora A kinase AurA

RCSB Kinase

Target Species: Human
Kinase Family: Aur
Kinase Group: Other
Mutation: No

Resolution: 2.78
Release Year: 2015

Kinase Alias: MGC34538, BTAK, STK7, STK15, AURORA2, AURA, AIK, AurA, STK6, ARK1, AURKA
Downstream Molecules: CPEB
Associated Diseases: Acute Myeloid Leukemia, Advanced Solid Tumor

Ligand ID: NL4

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu211, Tyr212, Ala213
Binding Data: IC50=0.036uM
Ligand SMILES: CN(C)C(=O)c1cccc(Cn2cc(c3c(Cl)cnc4nc(C5=C(NN(C5)C)C)[nH]c34)cn2)c1
Reference: 10.1016/j.bmcl.2015.08.003