5A4Q

Dual specificity tyrosine-phosphorylation-regulated kinase 1A DYRK1A

RCSB Kinase

Target Species: Human
Kinase Family: DYRK
Kinase Group: CMGC
Mutation: No

Resolution: 2.37
Release Year: 2015

Kinase Alias: MNBH, DYRK, DYRK1, HP86, DYRK1A, MNB
Downstream Molecules: GLI1, NFATc1
Associated Diseases: Down Syndrome, Antosomal Dominant Mental Retardation

Ligand ID: Y3L

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Met240, Leu241, Ser242
Binding Data: IC50=2.9uM
Ligand SMILES: [nH]1c2ccc(Cl)cc2s/c/1=N\C(=O)C
Reference: 10.1021/acs.jmedchem.6b01086