4ZS0

Aurora A kinase AurA

RCSB Kinase

Target Species: Human
Kinase Family: Aur
Kinase Group: Other
Mutation: No

Resolution: 3
Release Year: 2015

Kinase Alias: MGC34538, BTAK, STK7, STK15, AURORA2, AURA, AIK, AurA, STK6, ARK1, AURKA
Downstream Molecules: CPEB
Associated Diseases: Acute Myeloid Leukemia, Advanced Solid Tumor

Ligand ID: 4QV

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu211, Tyr212, Ala213
Binding Data: IC50=2.3uM
Ligand SMILES: O=c1[nH]c2cc(O)ccc2n1c1nc2ccccc2[nH]1
Reference: 10.1021/acs.jmedchem.6b00709