4YTI

Tyrosine-protein kinase JAK2

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 2.52
Release Year: 2015

Kinase Alias: JAK2
Downstream Molecules: STAT3, PI3K
Associated Diseases: Polycythemia Vera, Myelofibrosis

Ligand ID: VJK

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu930, Tyr931, Leu932
Binding Data: Ki=13nM
Ligand SMILES: C([C@](C)(C(=O)NCC(F)(F)F)Nc1ccnc(c2c[nH]c3c2cccn3)n1)C
Reference: 10.1021/acs.jmedchem.5b00301