4YJO

Tyrosine-protein kinase SYK

RCSB Kinase

Target Species: Human
Kinase Family: Syk
Kinase Group: TK
Mutation: No

Resolution: 1.6
Release Year: 2015

Kinase Alias: SYK
Downstream Molecules: BTK, BLNK, GAB2
Associated Diseases: Breast Cancer

Ligand ID: 4DF

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu449, Met450, Ala451
Binding Data: ~
Ligand SMILES: CCN(c1cccc2[nH]ncc12)c1nc(Nc2ccc3CNS(=O)(=O)c3c2)ncc1Cl
Reference: 10.1016/j.bmcl.2011.07.082