4Y72

Cyclin-dependent kinase 1 CDK1

RCSB Kinase

Target Species: Human
Kinase Family: CDK
Kinase Group: CMGC
Mutation: No

Resolution: 2.3
Release Year: 2015

Kinase Alias: DKFZp686L20222, CDC28A, MGC111195, CDK1, p34cdc2, CDC2
Downstream Molecules: Vimentin, Fun30, XIAP
Associated Diseases: Colorectal Cancer, Breast Cancer, Ovarian Cancer, Laryngeal Squamous Cell Carcinoma

Ligand ID: LZ9

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ser82, Leu83, Ser84
Binding Data: ~
Ligand SMILES: Fc1ccc(NC(=O)c2[nH]ncc2NC(=O)c2c(F)cccc2F)cc1
Reference: 10.1038/ncomms7769