4XV9

Serine/threonine-protein kinase BRAF

RCSB Kinase

Target Species: Human
Kinase Family: RAF
Kinase Group: TKL
Mutation: No

Resolution: 2
Release Year: 2015

Kinase Alias: RAFB1, BRAF1, B-raf 1, MGC138284, BRAF, MGC126806
Downstream Molecules: MEK1, MEK2,
Associated Diseases: Cancer, Metastatic Melanoma, Solid Tumors

Ligand ID: 1OO

RCSB Ligand

Ligand Type: Type II Inhibitor
Binding Pocket: ATP domain/Hydrophobic pocket
Key Interaction Residues: Gln530, Trp531, Cys532
Binding Data: IC50=0.19uM
Ligand SMILES: FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1c(F)c(c(cc1)F)C(=O)c1c[nH]c2c1cc(cn2)Cl
Reference: 10.1038/nature14982