4RJ7

Epidermal growth factor receptor EGFR

RCSB Kinase

Target Species: Human
Kinase Family: EGFR
Kinase Group: TK
Mutation: No

Resolution: 2.55
Release Year: 2014

Kinase Alias: ERBB, ERBB1, EGFR, mENA, EGFRvIII
Downstream Molecules: JAK, Src, Shc
Associated Diseases: Cancer

Ligand ID: 3R1

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Gln791, Leu792, Met793
Binding Data: Ki=22nM
Ligand SMILES: c1(cc(C)nc(n1)N[C@@H](C)CO)Nc1cc(ccn1)NC(=O)c1c(cccc1Cl)Cl
Reference: 10.1021/jm501578n