4QPS

Tyrosine-protein kinase JAK3

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 1.8
Release Year: 2014

Kinase Alias: JAKL, LJAK, JAK3, L-JAK, JAK-3, JAK3_HUMAN
Downstream Molecules: STAT3, PI3K
Associated Diseases: Non-Small Cell Lung Cancer, T-Cell Acute Lymphoblastic Leikemia

Ligand ID: 37Q

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu903, Tyr904, Leu905
Binding Data: IC50=0.30uM
Ligand SMILES: c1cc(ccc1)Nc1cncc(n1)n1c2cc(ccc2nc1)NC(=O)CC
Reference: 10.1074/jbc.M114.595181