4PS5

Bromodomain-containing protein 4

RCSB Kinase

Target Species: Human
Kinase Family: BRD
Kinase Group: Atypical
Mutation: No

Resolution: 1.4
Release Year: 2014

Kinase Alias: BRD4, MCAP, CAP, HUNKI
Downstream Molecules: NF-κB, c-MYC
Associated Diseases: Cancer

Ligand ID: 2TA

RCSB Ligand

Ligand Type: Competitive Inhibitor
Binding Pocket: BRD domain
Key Interaction Residues: Asn156, Ile162, Tyr155
Binding Data: IC50=0.29uM
Ligand SMILES: C1CCCN1CCOc1ccc(cc1)N[C]1=[N]=C(C(=CN=1)C)Nc1cc(ccc1)S(=O)(=O)NC(C)(C)C
Reference: 10.1021/cb500072z