4JAJ

Aurora A kinase AurA

RCSB Kinase

Target Species: Human
Kinase Family: Aur
Kinase Group: Other
Mutation: No

Resolution: 2.7
Release Year: 2013

Kinase Alias: MGC34538, BTAK, STK7, STK15, AURORA2, AURA, AIK, AurA, STK6, ARK1, AURKA
Downstream Molecules: CPEB
Associated Diseases: Acute Myeloid Leukemia, Advanced Solid Tumor

Ligand ID: XU1

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu211, Tyr212, Ala213
Binding Data: IC50=5.54uM
Ligand SMILES: c1cc2c3c([nH]c(=O)c2cc1)nccc3
Reference: 10.1016/j.bmcl.2013.03.008