4J3I

Bromodomain-containing protein 4

RCSB Kinase

Target Species: Human
Kinase Family: BRD
Kinase Group: Atypical
Mutation: No

Resolution: 1.24
Release Year: 2013

Kinase Alias: BRD4, MCAP, CAP, HUNKI
Downstream Molecules: NF-κB, c-MYC
Associated Diseases: Cancer

Ligand ID: 1K0

RCSB Ligand

Ligand Type: Competitive Inhibitor
Binding Pocket: BRD domain
Key Interaction Residues: Asn156, Ile162, Tyr155
Binding Data: IC50=1.8uM
Ligand SMILES: O(C)c1cc(OC)c2c(=O)nc([nH]c2c1)c1cc(C)c(OCCO)c(C)c1
Reference: 10.1371/journal.pone.0083190