4I4F

Focal adhesion kinase 1 FAK1

RCSB Kinase

Target Species: Human
Kinase Family: FAK
Kinase Group: TK
Mutation: No

Resolution: 1.75
Release Year: 2013

Kinase Alias: FAK1, pp125FAK, FADK, FAK, PTK2, FAKpp125
Downstream Molecules: PI3K, Paxillin
Associated Diseases: Breast Cancer, Advanced Clear Cell Renal Carcinoma

Ligand ID: 1BR

RCSB Ligand

Ligand Type: Competitive Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Leu501, Cys502, Thr503
Binding Data: IC50=0.64uM
Ligand SMILES: CN1c2ccc(NCc3ccc(cc3)C(C)(C)C)cc2c2c(cnn2C)S1(=O)=O
Reference: 10.1016/j.bmcl.2013.01.047