4HVB

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

RCSB Kinase

Target Species: Human
Kinase Family: PI3K/PI4K
Kinase Group: other
Mutation: No

Resolution: 2.35
Release Year: 2013

Kinase Alias: PIK3CG
Downstream Molecules: Akt, Itk
Associated Diseases: Breast Cancer, Myeloid Tumor

Ligand ID: 19P

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Ile881, Val882, Lys883
Binding Data: Ki=0.111nM
Ligand SMILES: c1(ccc2c(n1)c1c(cn2)n(c(=O)n1[C@H]1CCN(CC1)C(=O)[C@@H](O)C)C)c1cnc(cc1)C
Reference: 10.1021/ml300309h