4GII

Non-receptor tyrosine-protein kinase TYK2

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 2.31
Release Year: 2013

Kinase Alias: TYK2, JTK1
Downstream Molecules: STAT1, STAT2
Associated Diseases: Hyper-Ige Syndrome, T-Cell Acute Lymphoblastic Leukaemia

Ligand ID: 0X6

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu979, Tyr980, Val981
Binding Data: Ki=1.8nM
Ligand SMILES: c1(cc(ccn1)NC(=O)c1c(cc(cc1Cl)C#N)Cl)NC(=O)C1CC1
Reference: 10.1021/jm400266t