4F65

Fibroblast growth factor receptor 1 FGFR1

RCSB Kinase

Target Species: Human
Kinase Family: FGFR
Kinase Group: TK
Mutation: No

Resolution: 2.26
Release Year: 2012

Kinase Alias: HBGFR, H4, H2, C-FGR, CEK, FLJ14326, H5, N-SAM, KAL2, BFGFR, H3, FGFBR, CD331, LOC51033, FLT2, FLG, FGFR1
Downstream Molecules: GRB2, PLC, RAS
Associated Diseases: Breast Cancer, Trigonocephaly, Syndromic Craniosynostoses

Ligand ID: 0S9

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Tyr563, Ala564, Ser565
Binding Data: IC50=2.5nM
Ligand SMILES: c1ccc(cc1)CCc1cc([nH]n1)Nc1c(cnc(n1)NCc1cc(C)no1)Br
Reference: 10.1021/jm3004043