4BCF

Cyclin-dependent kinase 9 CDK9

RCSB Kinase

Target Species: Human
Kinase Family: CDK
Kinase Group: CMGC
Mutation: No

Resolution: 3.01
Release Year: 2013

Kinase Alias: CDC2L4, CDK9, PITALRE, C-2k, TAK
Downstream Molecules: GRIP1, Pirh2 protein
Associated Diseases: Lung Cancer, Pancreatic Cancer, Prostate Cancer

Ligand ID: T6Q

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Asp104, Ser105, Cys106
Binding Data: Ki=7nM
Ligand SMILES: CNc1nc(C)c(c2nc(Nc3cccc(N4CCCN(C(=O)C)CC4)c3)ncc2C#N)s1
Reference: 10.1021/jm301495v