4BBF

Tyrosine-protein kinase JAK2

RCSB Kinase

Target Species: Human
Kinase Family: Jak
Kinase Group: TK
Mutation: No

Resolution: 2
Release Year: 2012

Kinase Alias: JAK2
Downstream Molecules: STAT3, PI3K
Associated Diseases: Polycythemia Vera, Myelofibrosis

Ligand ID: O19

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu930, Tyr931, Leu932
Binding Data: IC50=2.2nM
Ligand SMILES: O=C([C@H]1CCC[NH2+]1)Nc1ccc(cc1)c1nc(ncc1)Nc1ccc(cc1)N1CCOCC1
Reference: 10.1016/j.bmcl.2012.10.007