4BB4

Ephrin type-B receptor 4 EPHB4

RCSB Kinase

Target Species: Human
Kinase Family: Eph
Kinase Group: TK
Mutation: No

Resolution: 1.65
Release Year: 2013

Kinase Alias: EPHB4, HTK, TYRO11, MYK1, EphB4
Downstream Molecules: Abl, RasGAP, Ephexin
Associated Diseases: Rhabdomyosarcoma, Chronic Myeloid Leukemia

Ligand ID: 32W

RCSB Ligand

Ligand Type: Type I Inhibitor
Binding Pocket: ATP domain
Key Interaction Residues: Glu694, Ser695, Met696
Binding Data: IC50=190nM
Ligand SMILES: O=C(NCCOC)c1ccc(cc1)Nc1nc2c(cn1)cc(cc2)c1ccncc1
Reference: 10.1021/jm301658d